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Sildenafil
Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
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Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth (tablets), IV
ATC codeG04BE03 ( WHO )
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Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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This article was reviewed by Brendan Levy, MD. Use of this heart medication with L-arginine might cause your blood pressure to become too low. As with all drugs and supplements, L-arginine should only be taken after speaking to your doctor about its potential effects on your health.

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The Facts About L-Arginine Supplements and Erectile Dysfunction

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L-arginine taking viagra on a plane reduce blood pressure in people who have high blood pressure. The effects of sildenafil, phentolamine, yohimbine and L-arginine were studied on the response of the RCC to electrical field stimulation EFS as well as on the phenylephrine PE, 3 x 10 -6 M -induced tone.

L-arginine improves blood flow. The current studies show mixed results, making it impossible to conclusively state that L-arginine has any real benefits as an erectile dysfunction treatment.

If you have an erection that lasts more than 4 hours, get medical help right away — possible side effects of amoxicillin. If you smoke, quit.

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L-Arginine Aids in the Treatment of Erectile Dysfunction

Concerns and side effects The research to support the use of L-citrulline as an ED treatment is limited. Other natural remedies for ED Not every man experiencing ED will want to use conventional prescription medications.

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Some supplements contain a mixture of L-citrulline and other ingredients. One study in the International Journal of Impotence Research found that about a quarter of the men in the study who received acupuncture had improved erections and were able to perform internet viagra pharmacy. However, there has been no large randomized clinical trial to assess the safety of L-citrulline for ED treatment.

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Also, one-third to one-half of supplements marketed as natural products actually contain synthetic chemicals. Sildenafil 1 x 10 -9 -1 x 10 l arginina viagra M and phentolamine 1 x 10 -9 -1 x 10 -6 M enhanced the EFS-induced relaxation in a concentration-dependent manner with ED50 of 0. Does this mean that L-arginine is worthless as a supplement?

Sildenafil 1 x 10 -9 and 1 x 10 -8 M potentiated the EFS-induced relaxation caused by L-arginine 3 x 10 -5 m.

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