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Sildenafil
Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
License dataEU  EMA:  by INN, US   FDA: Sildenafil
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth (tablets), IV
ATC codeG04BE03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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The medicine can only be obtained with a prescription. What were the reasons given by the company to withdraw the application? Pfizer also recommends that pharmacists should advise all men to follow up with their doctor within six months of first being supplied the product.

It says there are better potential matches, and that Novartis and Pfizer spring to mind. There are even fatal cases. There is http://tinadico.com/dostinex/buy-pfizer-viagra particular law, concerning over-the-counter medication regulation.

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Because erection problems can be a sign of an underlying disease, the Committee was concerned that switching the medicine to non-prescription use could delay or prevent the diagnosis of any underlying diseases, including coronary artery disease obstruction of blood flow to the heart muscle. This included information from previous studies looking at the http://tinadico.com/prometrium/safety-of-viagra-online safety and effectiveness, as well as information on the risks of the medicine being used incorrectly.

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Viagra is used to treat adult men with erectile dysfunction impotencewhich means that they cannot get or keep a hard penis erection sufficient for satisfactory sexual activity The problem The CHMP was concerned that Viagra 50 mg did not fulfil the criteria needed for switching its classification from prescription to non-prescription status A strong regulator increases confidence in drugs and devices
There is no particular law There is no particular law What is happening with Viagra as a prescription-only medicine?A new initiative that enables men to go to a pharmacy to get help for their erectile dysfunction is welcome
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Some criticise Gottlieb The head of the U How far into the evaluation was the application when it was withdrawn?A new initiative that enables men to go to a pharmacy to get help for their erectile dysfunction is welcome
Instead Takeda interest in Shire likely to inspire other offers The FT on Thursday says Takeda's interest in Shire is likely to inspire other potential buyers to show their hand Democracy estimating The company also provided details of the written information to be provided with the medicine
The drug has been been credited with revolutionising treatment for male impotence and reducing stigma surrounding the condition since its commercial launch in but has become a popular target for criminals We hope that this forthcoming new opportunity to purchase a genuine treatment via pharmacy will also reduce the likelihood of men turning to potentially ineffective and dangerous counterfeits from illicit sources In addition Novartis's CEO Dr Vasant Narasimhan on the other hand is exiting consumer health with funds from the GSK deal earmarked to expand 'core' areas of innovative prescription drugs

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Pfizer also recommends that pharmacists should advise all men to follow up with their doctor within six months of first being supplied the product. Expand all Collapse all What is Viagra?

AbbVie might have another go following its failed offer. Viagra 50 mg tablets were expected to be used for the same indication, but to be available without a prescription with herbal viagra for sale in ireland.

For the foreseeable future, it is hard to imagine any of the erectile dysfunction drugs becoming available over-the-counter. The CHMP was also concerned that the information to be provided with the medicine was too complex, which could lead to patients using the medicine incorrectly.

What were the reasons given by the company to withdraw the application? The drug has been been credited with revolutionising treatment for male impotence and reducing stigma surrounding the condition since its commercial launch in but has become a popular target for criminals. After the CHMP had assessed the responses from the company to a list of questions, there were still some unresolved issues outstanding.

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Some criticise Gottlieb, who once worked in the industry, for still being its accomplice. All drugs are presumed to be prescription. Pfizer has been training thousands of pharmacists on how best to consult people interested in buying Viagra Connect, which will be available in 14, stores across Britain and via pharmacy websites. Cheaper prices for medical remedies can be found only in Slovakia, Portugal, Estonia, and Latvia.

This included information from previous studies looking at the medicine's safety and source website, as well as information on the risks of the medicine being used incorrectly.

The letter from the company notifying the EMEA of the withdrawal of the application is available under the tab 'All documents'. All documents Overview On 19 NovemberPfizer Limited officially notified the Committee for Medicinal Products for Human Use CHMP that it wishes to withdraw its application for a change to the marketing authorisation for the medicinal product Viagra 50 mg tablets.

Therefore, at the time of the withdrawal, the CHMP was of the opinion that the benefits of Viagra 50 mg tablets as an over-the-counter treatment for erectile dysfunction did not outweigh its risks.

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Viagra is used to treat adult men with erectile dysfunction impotencewhich means that they cannot get or keep a hard penis erection sufficient for satisfactory sexual activity. There were no significant difficulties with this experiment.

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Comment №1 about product

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Because erection problems can be a sign of an underlying disease, the Committee was concerned that switching the medicine to non-prescription use could delay or prevent the diagnosis of any underlying diseases, including coronary artery disease obstruction of blood flow to the heart muscle. This included information from previous studies looking at the medicine's safety and effectiveness, as well as information on the risks of the medicine being used incorrectly.


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The manufacturer, Pfizer , said it hopes that Viagra Connect will go on sale over the counter in pharmacies in spring next year. We hope that this forthcoming new opportunity to purchase a genuine treatment via pharmacy will also reduce the likelihood of men turning to potentially ineffective and dangerous counterfeits from illicit sources.


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For the foreseeable future, it is hard to imagine any of the erectile dysfunction drugs becoming available over-the-counter. What was the recommendation of the CHMP at that time? While prescriptions of Viagra and other erectile dysfunction drugs containing sildenafil have tripled in Britain in a decade — there were 2,, prescriptions in , compared with 1,, in — there is still a large black market.


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