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Sildenafil
Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
License dataEU  EMA:  by INN, US   FDA: Sildenafil
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth (tablets), IV
ATC codeG04BE03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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This list of commonly prescribed drugs metabolized via the P 3A4 pathway includes: January 20, Published: The coadministration of one of these drugs may lead to competitive inhibition of the metabolism of sildenafil. The dose can be adjusted depending on the results.

Viagra for heart conditions experts agree that men who are taking nitrates cannot use ED pills; this includes all preparations of nitroglycerin short-acting, under-the-tongue tablets or sprayslong-acting nitrates isosorbide dinitrate or Isordil, Sorbitrate, and others, and isosorbide mononitrate, Imdur, ISMO, and othersnitroglycerin patches and pastes, and amyl nitrite or amyl nitrate so-called viagra under the counter, which some men use for sexual stimulation.

The overall incidence of cardiovascular adverse events is low and similar to placebo.

Sildenafil was initially investigated as a treatment for chest pain and high blood pressure and payment options. It should not be prescribed to patients on nitrates. Men who do not respond to a full dose on two or three different occasions should try other treatments. I had a major heart attack earlier this year and received a drug-eluting stent.

Sildenafil is potentially contraindicated in these 6 million patients. J Clin Endocrinol Metab. Thus, there are possible problems in the use of Viagra in these patients. A pill for impotence editorial N Engl J Med.

Use of sildenafil Viagra in patients with cardiovascular disease. The drugs come in several strengths.

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J Am Coll Cardiol. The drug is contraindicated in those taking organic nitrates.

Are ED pills safe for the heart? They help relax blood vessels and increase blood flow to the penis. Indeed, no one should use them viagra for heart conditions or recklessly, but 20 million American men have erectile dysfunction, and most can use them safely.

It should not be prescribed to patients on nitrates. Thus, potent inhibitors of the P 3A4 pathway may increase the plasma concentrations of sildenafil and its pharmacological effects. Faced with all these warnings, should any man use Viagra, Levitra, or Cialis? All arteries, not just those in the penis, discount viagra pfizer nitric oxide, so any artery can widen in response to Viagra, Levitra, or Cialis, causing blood pressure to drop temporarily by mmHg, even in healthy men.

Men who do not respond to a full dose on two or three different occasions should try other treatments. However, its actual effect on blood pressure is small and therefore not dangerous to men with heart disease. I had a major heart attack earlier this year and received a drug-eluting stent.

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SILDENAFIL (VIAGRA) AND THE HEART

The most common side effects include flushing, headaches, dyspepsia, and transient visual changes. Use of sildenafil Viagra in patients with cardiovascular disease. Headaches and blue vision are one thing, cardiac abnormalities, quite another.

Sildenafil acts as a selective inhibitor of cycle GMP-specific phosphodiesterase type 5, resulting in smooth muscle relaxation, vasodilation, and enhanced penile erection. These drugs are safe for healthy hearts, but all men with cardiovascular disease should take special precautions, and some cannot use them under any circumstances.

Faced with all these warnings, should any man use Viagra, Levitra, or Cialis? All online pharmacy viagra utah taking either sildenafil or nitrates must be warned of the contraindications and potential consequences of taking sildenafil within hour interval after taking a nitrate preparation, including sublingual nitroglycerin.

If patients are taking a combination of antihypertensive medications, they should be cautioned about the possibility of sildenafil-induced hypotension. Reduced dosage is also important for men with advanced age and for those with natural viagra options kidney or liver disease.

Because the effects of sildenafil have not been evaluated in patients with bleeding disorders or in patients taking non-aspirin antiplatelet agents e. Are erectile dysfunction pills safe for men with heart disease?

Reduced dosage is also important for men with advanced age and for http://tinadico.com/propecia/side-effects-of-propecia-depression with significant kidney or liver disease.

Additionally, nitrates should not be administered to anyone who has recently ingested sildenafil. azithromycin in the treatment of sexually transmitted disease. Sexual activity after a myocardial infarction. Because certain medications can boost the blood levels of these viagra for heart conditions, men taking erythromycin or certain antifungal or anti-HIV medications should use only low-dose PDE-5 inhibitors.

Viagra for heart conditions
The results of the study - which will be published in a forthcoming issue of the viagra and heart conditions BMJ Heart - on 6 Thus Most men should start with a low to moderate dose Cimetidine and erythromycin are commonly prescribed drugs that inhibit the P 3A4 pathway
All arteries Are ED pills safe for the heart?All experts agree that men who are taking nitrates cannot use ED pills Physicians should be aware of the potential interaction of such agents
Are ED pills safe for the heart?They help relax blood vessels and increase blood flow to the penis Sildenafil acts as a selective inhibitor of cycle GMP-specific phosphodiesterase type 5 Int J Clin Pract
The dose can be adjusted depending on the results Are erectile dysfunction pills safe for men with heart disease?January 20 J Clin Endocrinol Metab

In Graphics: Viagra can cut heart attack risk

Because certain medications can boost the blood levels of these drugs, men taking erythromycin or certain antifungal or anti-HIV medications should use only low-dose PDE-5 inhibitors. The most common side effects include flushing, headaches, dyspepsia, and transient visual changes.

Impotence and its non-surgical management. January 20, Published: Patients should be given clear instructions regarding the use of sildenafil. Cimetidine and erythromycin are commonly prescribed drugs that inhibit the P 3A4 pathway.

See What Happened To This 74 Year Old Man After He Took Two Viagra Tablets – Ray Boddington:

Reduced dosage is also important for men with advanced age and for those with significant kidney or liver disease. All experts agree that men who are taking nitrates cannot use ED pills; this includes all preparations of nitroglycerin short-acting, under-the-tongue tablets or sprayslong-acting nitrates isosorbide viagra for heart conditions or Isordil, Sorbitrate, and others, and isosorbide mononitrate, Imdur, ISMO, and othersnitroglycerin patches and pastes, and amyl nitrite or amyl nitrate so-called poppers, which some men use for sexual stimulation.

Indeed, no one should use them needlessly or recklessly, but 20 million American men have erectile dysfunction, and most can use them safely. The drugs come in several strengths.

Organic nitrate pills are frequently prescribed to help relieve and prevent the symptoms of angina pectoris. Shipping has been timely. Furthermore, conclusive studies have never been done on patients with uncontrolled hypertension, heart failure, myocardial infarction or people who have suffered a recent stroke.

Sildenafil is predominantly metabolized by both the P 2C9 and the P 3A4 pathways. Synergetic blood pressure lowering has not been observed when sildenafil was used with other classes of antihypertensives.

Thus, the duration of activity of sildenafil may be does viagra increase sensitivity and the extent of its viagra for heart conditions enhanced. Although the metabolic demands of sexual activity are modest and the associated risk for coronary events is low, the clinician caring for cardiac patients needs to be aware of the pharmacology and hemodynamic profile of sildenafil in those with heart disease who use cardioactive drugs.

All arteries, not just those in the penis, generate nitric oxide, so any artery can widen in response to Viagra, Levitra, or Cialis, causing blood pressure to drop temporarily by mmHg, even in healthy men or sildenafil price comparison. Are ED pills safe for the heart?

The simultaneous administration of either of these agents significantly increases the plasma concentration of sildenafil; a lower initial dose 25 mg rather than the recommended 50 mg should be considered in the coadministration of sildenafil to patients receiving either of these agents. The only difference is that nitrates are contraindicated for these patients or exelon 4 6 mg 24 h.

Sildenafil is predominantly metabolized by both the P 2C9 and the P 3A4 article source. Because the effects of sildenafil have not been evaluated in patients with bleeding disorders or in patients taking non-aspirin antiplatelet agents e. In patients who inadvertently received nitrates while taking sildenafil and who manifest a severe hypotensive response, it is essential to have the capability to support the patient with fluid resuscitation and alpha-adrenergic agonists.

Symptoms can include fatigue, shortness of http://tinadico.com/aygestin/ship-free-viagra-sample and swelling. All experts agree that men who are taking nitrates cannot use ED pills; this includes all preparations of nitroglycerin short-acting, under-the-tongue tablets or sprayslong-acting nitrates isosorbide dinitrate or Isordil, Sorbitrate, viagra and heart disease others, and isosorbide mononitrate, Imdur, ISMO, and othersnitroglycerin patches and pastes, and amyl nitrite or amyl nitrate so-called poppers, which some men use for sexual stimulation.

Headaches and blue vision are one thing, cardiac abnormalities, quite another.

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Viagra, 5 reviews:

Comment №1 about product

The only difference is that nitrates are contraindicated for these patients. Sexual activity after a myocardial infarction.


4 / 5 stars
Comment №2 about product

Because certain medications can boost the blood levels of these drugs, men taking erythromycin or certain antifungal or anti-HIV medications should use only low-dose PDE-5 inhibitors. In combination with nitrates, it can and has caused fatal hypotension.


2 / 5 stars
Comment №3 about product

The three rivals -- Viagra, Cialis, and Levitra -- have similar side effects, including headache, facial flushing, nasal congestion, diarrhea, backache, and, in a few Viagra or Levitra users, temporary impaired color vision men with retinitis pigmentosa, a rare eye disease, should check with their ophthalmologists before using these medications. This list of commonly prescribed drugs metabolized via the P 3A4 pathway includes:


1 / 5 stars
Comment №4 about product

Additionally, nitrates should not be administered to anyone who has recently ingested sildenafil. Are ED pills safe for the heart? Sildenafil is absolutely contraindicated in patients taking any long-acting nitrates or using short-acting nitrates because of the risk of developing potentially life-threatening hypotension.


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Men with potential problems should always start with the lowest dose. The three rivals -- Viagra, Cialis, and Levitra -- have similar side effects, including headache, facial flushing, nasal congestion, diarrhea, backache, and, in a few Viagra or Levitra users, temporary impaired color vision men with retinitis pigmentosa, a rare eye disease, should check with their ophthalmologists before using these medications. Riley AJ, Athanasiadis L.


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